Learn what medications may be dangerous for your dog with the MDRI genetic mutation.
Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses.
Once WSU has determined your dog’s MDR1 status, board- certified veterinary pharmacologist Dr. Katrina Mealey, who discovered the MDR1 genetic mutation in dogs and cats, can work with you and your veterinarian through MDR1Caddie™ to determine the best course of action should your pet need to be treated with a medication known to cause adverse reactions.
Problem medications
The list of problem medications for dogs and cats is kept current and includes only drugs that have undergone peer-reviewed publication. Updates to this list occur as new research is published. For the most up-to-date dosing recommendations, including drugs currently under investigation, please submit questions through MDR1Caddie.
| Drug (Active Ingredient) | Brand Name | Recommendation |
|---|---|---|
| Acepromazine | Contact MDR1Caddie™ for dosing recommendations | |
| Afoxolaner | Nexgard | The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. No adverse effects were observed. Dogs with the MDR1 mutation are not at increased risk for adverse effects. |
| Apomorphine | Contact MDR1Caddie™ for dosing recommendations | |
| Butorphanol | Torbugesic | Contact MDR1Caddie™ for dosing recommendations |
| Chemotherapy | Contact MDR1Caddie™ for dosing recommendations | |
| Cyclosporine | Atopica | Contact MDR1Caddie™ for dosing recommendations |
| Doxorubicin | See Chemotherapy | |
| Fluralaner | Bravecto | The manufacturer of Bravecto has tested the product for safety in dogs with the MDR1 mutation. No adverse effects were observed. Dogs with the MDR1 mutation are not at increased risk for adverse effects. |
| Grapiprant | Galliprant | Contact MDR1Caddie™ for dosing recommendations |
| ivermectin | Heartgard Plus | The manufacturer of Heartgard has tested the product for safety in dogs with the MDR1 mutation. No adverse effects were observed. The FDA determined Heartgard is safe for dogs with the MDR1 mutation when used at label doses. For other formulations of ivermectin contact MDR1Caddie™ for dosing recommendations. |
| Loperamide | Imodium | At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. This drug should be avoided in all dogs with the MDR1 mutation. |
| Milbemycin | Interceptor, Interceptor Plus | The manufacturer of Interceptor has tested the product for safety in dogs with the MDR1 mutation. No adverse effects were observed. The FDA determined Interceptor is safe for dogs with the MDR1 mutation when used at label doses. For other formulations of milbemycin contact MDR1Caddie™ for dosing recommendations. |
| Maropitant | Cerenia | Contact MDR1Caddie™ for dosing recommendations |
| Moxidectin | ProHeart, Simparica Trio, Nexgard Plus, Advantage Multi | The manufacturers of these products have tested the product for safety in dogs with the MDR1 mutation. No adverse effects were observed. The FDA has determined that these products are safe for dogs with the MDR1 mutation when used at label doses. |
| Ondansetron | Contact MDR1Caddie™ for dosing recommendations | |
| Sarolaner | Simparica | The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 mutation. No adverse effects were observed. Dogs with the MDR1 mutation are not at increased risk for adverse effects. |
| Vinblastine | See Chemotherapy | |
| Vincristine | See Chemotherapy | |
| Vinorelbine | See Chemotherapy | |
| Selamectin | Revolution | The manufacturer of Revolution has tested the product for safety in dogs with the MDR1 mutation. No adverse effects were observed. The FDA determined Revolution is safe for dogs with the MDR1 mutation when used at label doses. |