Small Animal Liver Panel

Small Animal Liver Panel


Dog and Cat looking at the camera


Elevation in liver enzymes is a relatively common finding in our small animal patients. While monitoring trends in liver enzymes can help to guide nonspecific hepatoprotectant therapy, a specific diagnosis cannot be made without histologic examination. Similarly, although gross changes via ultrasonographic studies or at surgery are also relatively common, these changes are often nonspecific and require histologic examination.

Although a great deal of information can be obtained via standard H&E histology, a more thorough histologic examination should include evaluation of fibrosis, copper, pigments, and potentially glycogen or bile. These parameters are best evaluated via the application of a panel of special stains. The additional information gained can provide invaluable information on the chronicity and activity of a lesion, complicating factors, and ultimately the prognosis.

Samples, Tests & Fees

The samples and tests listed below are suggested to detect and quantify common and important causes of liver disease and dysfunction in small animals. Histologically this includes the presence, location and degree of copper accumulation and fibrosis, as well as pigment accumulation. The panel also includes quantification of liver copper and assessment for bacterial infection via aerobic and anaerobic cultures. Pricing includes special stains on up to two separate liver samples, which will be determined and ordered by the assigned pathologist. Please allow 5 days for results due to the additional stains.

We are switching from paper accession forms to an online ordering system which will expedite the sample testing process.

If you don’t have an online account, please go to to enroll (it takes 1-2 minutes). Once approved, you’ll receive an email with a link to submit your order, or you can go directly to the  WADDL Client Portal.

This 4-step submission process will take you through a series of questions to ensure all required information is provided, so when your package arrives, samples are moved quickly to their testing section(s). Additionally, if you have multiple animals to test, there is an upload function which will save time. If any questions arise, the consulting pathologist will be notified and may contact the submitter.

You may log in at any time to view the status of your order, ensure it was received, and view/print results.


For more details and current prices (including out-of-state pricing), go to the Web Test Search Tool and type “Liver” in the query field.

Small Animal Liver Panel

SamplesPreservationTestSpecial Stains IncludedWA Fee
Fixed LiverFixed in 10% buffered neutral formalin.Histopathology (H)

Trichrome, Reticulin, Iron, Copper;


PAS, lipofuscin, bile- as needed

Fresh (unfixed) TissueFresh chilled.

Aerobic and Anaerobic culture (B).


Copper Quantification (T).


Small Animal Liver Panel (HISTO ONLY)

SamplesPreservationTestAdditional Special StainsWA Fee
Fixed LiverFixed in 10% buffered neutral formalin.Histology (H)

Trichrome, Reticulin, Iron, Copper; 


PAS, lipofuscin, bile- as needed



Dr. Laura White